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Fluorescence intensity was measured at 530–590 nm using a CLARIOstar® microplate reader (CLARIOstar®, BMG LABTECH, Germany)

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Size:12ml

Adipose tissue-derived free fatty acids (FFAs) impair renal urate excretion via URAT1 upregulation, while hyperuricemia reciprocally induces insulin resistance and endothelial dysfunction through AMPK inhibition and oxidative stress (Xu et al., 2015)