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After maturation and integration in the neural circuit, the new neurons are indistinguishable from those generated during embryonic development, but it is their hyperexcitable nature during maturation that gives the hippocampus its plasticity and particular cognitive functions (Kempermann et al., 2+ /calmodulin-dependent protein kinase II (α-CaMKII) heterozygous knockout, showed that the dentate gyrus granule cells were arrested at a stage with similar molecular and physiological properties to those of the immature neurons (Yamasaki et al., 2008
