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An in vivo brain delivery versus controls study resulted in observed concentration-time profiles for unbound MTX in brain interstitial fluid and blood following intravenous infusion of free MTX, PEG liposomal MTX, and GSH-PEG liposomal MTX whereby Kp,uu increased ~10x (from 0.09 ± 0.05 to 0.82 ± 0.59)

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In a letrozole-induced PCOS rat model, DCI (50 mg/kg) alone or in combination with Ecklonia cava extract (250 mg/kg) significantly reduced pro-inflammatory cytokine TNF- α and IL-6 levels, attenuating systemic inflammation (61)