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Its molecular structure was optimized through genetic engineering technology: an additional 13 amino acids were added to the N-terminus of natural IGF-1 (70 amino acids, molecular weight 7.4 kDa) to form a long-chain structure of 83 amino acids (molecular weight 9.11 kDa), and the third glutamic acid (Glu) was replaced with arginine (Arg), hence the name "R3"
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In premenopausal women or those on hormonal contraceptives, this shift may lead to misleading laboratory readings such as normal total T4 with low fT4 and symptoms of hypothyroidism
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