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Moreover, evidence supporting EGCG’s neuroprotective effects via BBB-mediated anti-neuroinflammation and reduction of oxidative stress includes: (i) EGCG enhances dopamine neuron activity in the gut, decreases serotonin levels in the colon, and increases hippocampal 5-hydroxytryptamine levels by enhancing intestinal permeability (215–217)

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Of note, as mentioned, BPC 157 may counteract the isoprenaline-induced damage since the very beginning (i.e., 30 min) as it markedly attenuated the early isoprenaline-induced occlusion-like syndrome