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Conversely, the concentration of curcumin in colonic tissue was found to be higher than the plasma levels of this polyphenol after supplementation with doses ranging from 3 to 66 g of curcumin per day (Garcea et al., 2005) and with a dose of 3.25 g (Irving et al., 2013), suggesting the potential pharmacological significance of the large intestine for curcumin’s effects

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doi: 10.1080/14712598.2020.1727439