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Lian Li designed an injection hydrogel in situ that can respond to the enriched ROS at the trauma site, enabling the local delivery and on-demand release of ACCO and anti-inflammatory agents (Figure 13b) (Li et al., 2022)

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It is noteworthy that, although our current treatment regimen demonstrates low activity in inducing an acute, high lever release of pro-inflammatory cytokines with reduced tolerability, this issue may need further investigation during long-term exposure

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