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Curcumin mitigated the neurotoxic effects induced by glutamate through the inhibition of endoplasmic reticulum stress-associated activation of TXNIP/NLRP3 inflammasome in a manner that relied on 5’ AMP-activated protein kinase, as documented in reference ( 7 BBB breakdown While it is technically considered part of the primary injury, the breach of the blood-brain barrier (BBB) plays a role in the development of brain edema, which is a critical early element of secondary injury cascades (SIC) associated with various forms of brain injury (Mendes Arent et al., 2014)
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The aqueous stability of BSO-OxOAc in phosphate buffer (pH 7.4), as well as its reduction kinetics with a 10-fold excess of ascorbic acid (AA) were measured by ultra-high-performance liquid chromatography (UHPLC)