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In detail, the generated DHFR-TS model showed four main structural features: one hydrogen bond acceptor (HBA), three hydrogen bond donors (HBD), one hydrophobic (HY) and one negative ionizable (NI) with a selectivity score of 14.289, whereas the generated PTR1 model exhibited six main structural features: one HBA, two HBD, one HY, two aromatic rings (RA) with a selectivity score of 11.429
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In addition, the MDD participants typically demonstrated mild symptoms, and cases of severe MDD were underrepresented, which may reduce the effect sizes and the statistical power to detect significant groupwise differences or correlations with symptom scores