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For instance, the secretion of interferon gamma (IFN-γ) by CD8+ T cells has been shown to down-regulate the expression of SLC3A2 and SLC7A11 in tumor cells, leading to a disruption in cystine uptake ( Myeloid-derived suppressor cells (MDSCs) express the transporter SLC7A11, which selectively transports cystathionine but does not export cysteine
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Mechanisms of gamma-glutamylcysteine ligase regulation
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