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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

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Remodeling of calcium signaling is closely associated with the development of hormone-sensitive, castration-resistant, and highly aggressive PCa subtypes, directly regulating the responsiveness of PCa to anti-androgen therapies