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Therefore, the release of free iron from hepatic iron death significantly promotes the initiation of the inflammatory cascade

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The increased ROS level stimulates the proliferation and survival of cancer cells through various signaling pathways, including MAPK/extracellular‐regulated kinase (ERK) pathway, phosphoinositide‐3‐kinase (PI3K)/AKT pathway, and protein kinase D (PKD)/NF‐κB pathway [145]