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NSAID-Induced Gut Damage: A Specific Research Context Non-steroidal anti-inflammatory drugs (NSAIDs) cause significant gastrointestinal damage through prostaglandin synthesis inhibition — prostaglandins are critical for mucosal maintenance, and their suppression leads to reduced mucus production, decreased bicarbonate secretion, and impaired mucosal blood flow

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Researchers observed reduced body weight gain alongside smaller adipocyte size after NNMT suppression