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These endoperoxides tend to cyclize again to form the diendoperoxides 16( E )-10( S )(12( R ));13( S )(15( R ))-diepidioxy-9( R / S )-HpOME and 8( E )-10( R )(12( S ));13( R )(15( S ))-diepidioxy-16( R / S )-HpOME as well as their enantiomers, which were reported for the first time by Neff et al