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Interestingly, the authors emphasized the function of IFI27, with expression that correlated negatively with CD4 + T-cell counts, and obtained a good score as a biomarker to distinguish INR from IR patients, as shown in another study (78)

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To preserve or restore the barrier, possible strategies include pairing mucolytics with hydrating agents (such as hypertonic saline or surfactants) and developing synthetic mucus mimetics or hydrogels