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The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else.¹⁹ Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug — bupropion-naltrexone, whose users are also losing weight, which rules out the deficit as the cause.¹⁹ Semaglutide is informative here precisely because it is GLP-1-only: it carries the strongest version of this signal in the class while engaging no GIP or glucagon receptor, which locates the effect at the GLP-1 receptor rather than anywhere else
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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Solmonson A., DeBerardinis R.J
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