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Because the small probes creatinine and 4 kDa dextran, cross the unrestricted pathway more readily than 70 kDa dextran, changes in creatinine-to-70 kDa dextran and 4 kDa dextran to-70 kDa dextran fluxes be seen, but are smaller than increases in creatinine or 4 kDa dextran fluxes (Fig

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Hofmann SG, Gómez AF