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Oral delivery of ET significantly prevented major depressive disorder (MDD)-like social avoidance and sleep abnormalities in a social defeat stress (SDS) model in rats (83)

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Besides, SCO significantly reduced the expression of GFAP and Iba1 in the cortex of epileptic mice and inhibited the expression of CXCL-1, IL-1β, TNF-α, MCP-1, IL-6, HIF-1 and HMGB1, thereby protecting mice from pilocarpine-induced seizures by inhibiting Casapse-3 fragmentation, activation of astrocytes and microglia, inflammation and cell apoptosis through the TLR4/NF-κB pathway (64)