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Moreover, patients with AA generally have fewer comorbidities than those with rheumatoid arthritis, and rates of serious infections, HZ, MACE, venous thromboembolism (VTE), and malignancy are lower in dermatologic vs rheumatologic populations.25 Overall, IRs for MACE and VTE in the ALLEGRO clinical program were 0.14/100 PY and 0.06/100 PY, respectively