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It is worth noting that in clinical trials related to curcumin and NDDs, a clinical trial related to Amyotrophic Lateral Sclerosis (ALS) showed that nanocurcumin could improve the survival rate of ALS patients, while the results of a clinical trial related to PD did not show the efficacy of curcumin on PD, and the clinical trial of curcumin in combination with IFN β-1a for MS has not been conclusive due to high patient dropout rates and has not confirmed the neuroprotective effect of curcumin (Ghodsi et al., 2022