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To this end, we have chosen 6 kinases from the common set (the JNK3 target, and 5 off-target kinases: INSR, IRAK1, KIT, PDGFRB as off-targets from the JNK-IN-8 study and TNK1 as an off-target from the 1a R -IN-8 study) and an additional kinase, the homolog of TNK1 without a P-loop cysteine (ACK1/TNK2) and had them tested in the Eurofins DiscoverX platform at 1 μM concentration with JNK-IN-8, 1a R -IN-8, and 6 S,S -IN-8
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The molecules related to T-cell exhaustion can serve as biomarkers to predict CAR-T cell therapy efficacy and persistence
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