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Senescent Cell Clearance FOXO4-p53 interaction disruption – FOXO4-DRI binds to p53 , preventing its interaction with endogenous FOXO4 p53 activation – Freed p53 translocates to the nucleus and activates pro-apoptotic genes Apoptosis induction – Senescent cells undergo programmed cell death Immune clearance – Macrophages and other immune cells remove the apoptotic senescent cells 2
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