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Signs Dehydration May Be Affecting Your Brain You might notice: Brain fog Difficulty concentrating Forgetfulness Slower thinking Trouble making decisions Irritability Fatigue Headaches Feeling mentally "off" Slower reaction times Many people assume these symptoms are caused by stress, lack of sleep, or too much caffeine

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The rest of the 14-residue sequence, including whatever secondary structure or folding tendency it has in solution, is unchanged, which is why the two peptides are expected to behave similarly outside of that specific terminal-residue chemistry