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One of the review articles published by members of our lab explicitly explained how obesity has become a modern man's fertility nemesis ( Figure 4 Both animal and human studies have provided evidence that obesity indeed can impair male fertility (132–136)

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However, profound GSH depletion converts cell death induced by a variety of agents from apoptosis to necrosis (Hall, 1999), suggesting very high levels of ROS may overwhelm the apoptotic machinery