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In mammals, three types of TrxRs have been characterized: the cytosolic form TrxR1 (also known as TR1 or TXNRD1) 4 , the mitochondrial form TrxR2 (also known as TR3 or TXNRD2) 5,6 , and thioredoxin glutathione reductase (TGR, also known as TrxR3, TR2 or TXNRD3) that occurs in the microsomal fraction of testis tissue 7

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