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The most important subset of protein misfolding diseases includes conditions whose molecular basis can be traced back to a toxic “gain-of-function”, whereby specific peptides/proteins in their unstable, misfolded state self-organize into insoluble, cytotoxic, ordered and stable fibrillar polymeric assemblies with shared conformational features (amyloid aggregates) [8]

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Both men and women experience this form of hair loss, though the pattern differs: men typically see recession at the temples and thinning at the crown, while women more often see diffuse thinning across the top of the scalp