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CRBN–pomalidomide recognizes a three-consecutive-ZF degron To dissect how multiple ZFs engage the CRBN–MGD complex, we generated a deep mutational scanning (DMS) library of 89,918 single-point mutations from 124 dual-ZF binders

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[1] Both peptides maintain research-only status with the FDA, meaning no approved therapeutic indications exist, which directly impacts pricing structure since insurance coverage remains unavailable and access occurs only through research protocols or investigational use programs