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CBC interacts with ECS, but its affinity for CB1 and CB2 receptors is relatively low compared to cannabinoids like THC [25]

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Two complementary lineages—system Xc − inhibitors and GPX4-directed agents—offer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index