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The four low penetrating genes analyzed in the present study indicate that mutations in enzymes that lead to an inefficient detoxification associated with exposure to endogenous or exogenous estrogens during life, might be a trigger to hormone-dependent breast cancer development at later ages

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Tyrosinase is an integral enzyme in melanogenesis (the process by which melanin is produced) Inhibition of this enzyme significantly affects the levels of melanin (the pigment that imparts color to your skin, the higher the levels darker the skin)