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For example, mice lacking the laminin 511 α5 chain in the small intestinal basement membrane compensate by depositing colonic laminins (laminin 111 and laminin 411), which results in the transformation of the small intestine to a tissue with a colon-like mucosal architecture characterized by high levels of cell proliferation, probably owing to decreases levels of the cell cycle regulator cyclin-dependent kinase inhibitor B (CDKN1B) 42 (FIG
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