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In vitro , the exposure of rat proximal tubular cells to high concentrations of autologous albumin led to proteolytic cleavage and release of the N-terminal 24-residue fragment of albumin (ALB 1 − 24 ), which was further processed by dendritic cells into antigenic peptides that were loaded on MHC class I for presentation to and activation of CD8 + T cells ( 1 − 24 activated syngeneic CD8 + T cells in primary culture ( + and CD8 + T cell activation in vitro ( + T cells is an intriguing possibility that remains to be tested