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Funding Statement This work was supported by funds from Sapienza University of Rome and partially by the Project PON 01_01802 (to ATP)

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Typical evaluation window: 4–8 weeks At reassessment: continue if benefit exceeds risk discontinue if no measurable improvement simplify if side effects occur Bottom line for Meto readers If your goal is fat loss with metabolic improvement, the most defensible “stack” typically looks like: Evidence-based metabolic therapy (when appropriate) Resistance training + protein strategy Sleep and recovery fundamentals Targeted adjuncts only when there’s a clear mechanistic gap and measurable endpoints Peptide stacking can be intellectually interesting