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In parallel, activation of Y5 receptors promotes mitogenic activity through ERK pathway activation and suppression of cAMP signaling, reinforcing NPY’s contribution to tumor cell proliferation [75]

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MATERIALS AND METHOD METHODOLOGY Animals and grouping The animals involved in the study were maintained and used in accordance with the Animal Welfare Act and the Guide for the Care and Use of Laboratory animals prepared by the Ahmadu Bello University Committee on Animal Use and Care (ABUCAUC)