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Following an initial event of RCD, DAMPs accumulation can trigger tissue inflammation which can further promote RCD to form a self-amplified circuit of necro-inflammatory loop that leads to exaggerated cell death and inflammation, eventually resulting in tissue damage and organ dysfunction [48, 49]

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Acknowledgments We would like to thank our colleagues at the College of Pharmacy of the University of Mosul and at the Nineveh Health Directorate for their guidance and support