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[DOI] [PubMed] [Google Scholar] 125.Cheng H, Wang M, Li JL, Cairns NJ, Han X
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The amino acid oxidase interleukin-4-induced-1 (IL4i1), originally discovered as a gene induced in B cells in response to IL-4, generates the metabolite indole-3-pyruvate, which suppresses ferroptosis both through a radical scavenging mechanism and by orchestrating a gene expression profile that attenuates ferroptosis (Zeitler et al., 2021) (Figure 2)