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GPX4 plays a critical role in counteracting ferroptosis by mitigating lipid peroxidation, while other factors like nicotinamide adenine dinucleotide phosphate (NADPH) and coenzyme Q10 (CoQ10) also contribute to ferroptosis regulation ( In addition to these well-characterized mechanisms, recent studies have highlighted alternative ferroptosis surveillance pathways that operate independently of GPX4

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During starvation, when even glycogen stores are depleted, hepatocytes are able to convert amino acids derived from ingested and body proteins to glucose