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Another approach for enhancing the production of singlet oxygen species that are crucial for PDT activity is using molecules that promote intersystem crossing such as heavy atoms like aza-BODIPY (iodine substituted butoxy-aza-BODIPY, IBAB) molecules along with employing electron rich polymers for building the nanosystems so that there is creation of an electron rich environment which produces O 2 •− radicals in excess even in hypoxic conditions [182]