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It has been proposed that, like iron, Mn in plasma is oxidized from Mn 2+ to the Mn 3+ valence state by the ferroxidase enzyme ceruloplasmin and loaded onto plasma Tf for circulating into tissues (Martinez-Finley et al., 2012)
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Yang et al .[89] in their study with male C57BLKS/J background, Lepdb/Lepdb ( db/db ) and non-diabetic control Lepdb/m ( db/m ) mice showed that QE treatment was linked with a reduction in liver swelling, normalization of liver enzymes, and reduced hyperglycemia and lipid accumulation in the liver of db/db mice
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