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Gelam honey also reduces EMT by upregulating E-cadherin and downregulating Twist and the transcription factor Snail in colorectal cancer models ( Similar anti-metastatic effects have been noted for caffeic and gallic acids, which downregulate MMP and VEGF expression in melanoma and breast cancer cells (126)

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While prebiotics show promise in reducing intestinal permeability, further research is needed to identify which populations benefit most and the optimal prebiotic formulation for the given indication