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Limpawattana P, Inthasuwan P, Putraveephong S, Boonsawat W, Theerakulpisut D, Sawanyawisuth K
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At present, the clinical therapeutic drugs in Western medicine mainly include the following categories: fibrates, HMG-CoA reductase inhibitors (statins), proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, sodium-glucose transporter-2 inhibitors (SGLT2i), glucagon-like peptide-1 (GLP-1) receptor agonists, renin angiotensin aldosterone system (RAAS) blockers etc ( Firstly, as an activator of PPARα, fibrates can improve fatty acid β oxidation and lipid accumulation in DKD mice through AMPK/FOXA2/MACD pathway, and alleviate apoptosis of renal tubular cells ( According to the theory of TCM, lipid metabolism disorder belongs to the categories of “phlegm turbidity”, “qi stagnation” and “blood stasis”