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ANIMAL EXPERIMENTS ESSENTIAL FOR THE UNDERSTANDING OF HUMAN INSULIN-GH-IGF AXIS PHYSIOLOGY Insulin, IGF-I, and IGF-II and Their Receptors Efstratiadis’ series of knock-outs of the insulin-GH-IGF-axis in mice in the early 1990s clearly confirmed its importance in fetal and postnatal growth and metabolism (21)

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CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung

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