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ROS generation in various types of exercise In skeletal muscle, both enzymatic (e.g., glutathione peroxidase (GPx) and catalase) and non-enzymatic (e.g., GSH, uric acid, bilirubin, vitamin E, vitamin C, etc.) antioxidants function as a unified complex to scavenge ROS (Powers and Jackson, 2008)

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In patients susceptible to HS, these units undergo a cytokine-mediated hyperinflammation process causing hyperkeratosis and resulting follicular unit blockage